Hdac8 Gene Summary [Rat]
Enables chromatin binding activity and deacetylase activity. Involved in several processes, including cellular response to forskolin; cellular response to trichostatin A; and negative regulation of macromolecule metabolic process. Predicted to be located in chromosome; cytoplasm; and nucleus. Biomarker of amphetamine abuse; hypertension; and renovascular hypertension. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 5 and Wilson-Turner syndrome. Orthologous to human HDAC8 (histone deacetylase 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hdac8 |
| Official Name | histone deacetylase 8 [Source:RGD Symbol;Acc:1562895] |
| Ensembl ID | ENSRNOG00000003122 |
| Bio databases IDs | |
| Aliases | histone deacetylase 8 |
| Synonyms | 2610007D20Rik, CDA07, CDLS5, HD8, HDACL1, histone deacetylase 8, KDAC8, LOC100911968, LOC103690124, MRXS6, RGD1562895, RPD3, WTS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hdac8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Hsp70 protein binding
- heat shock protein binding
- chromatin binding
- transcription factor binding
- enzyme
- protein binding
- deacetylase
- Arginase-like and histone-like hydrolases
- phosphorylation site
- protein deacetylase activity
- linear amide carbon-nitrogen bond hydrolase
- histone deacetylase
Pathways
Biological processes and signaling networks where the Hdac8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Calcium Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of NFAT in Cardiac Hypertrophy
- Small Cell Lung Cancer Signaling
- Telomerase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- diffuse large B-cell lymphoma
- angioimmunoblastic T-cell lymphoma
- hereditary disorder
- organismal death
- Cornelia de Lange syndrome type 5
- relapsed peripheral T-cell lymphoma
- mental retardation
- B-cell non-Hodgkin disease
regulated by
- SOX4
- chrysin
- neomycin
- vancomycin
- metronidazole
- ampicillin
- givinostat
- tubacin
- dacinostat
- valproic acid
role in cell
- growth
- phosphorylation in
- expression in
- proliferation
- apoptosis
- cell death
- transcription in
- differentiation
- recovery
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hdac8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of protein stability
- mitotic sister chromatid cohesion
- negative regulation of protein ubiquitination
- chromatin organization
- regulation of gene expression, epigenetic
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- histone deacetylase complex
- nuclear chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase activity
- metal ion binding
- Hsp90 protein binding
- protein deacetylase activity
- Hsp70 protein binding