Tbx6 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in cell fate specification; negative regulation of DNA-binding transcription factor activity; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of neuron maturation; regulation of gene expression; and somite rostral/caudal axis specification. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 5. Orthologous to human TBX6 (T-box transcription factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbx6 |
| Official Name | T-box transcription factor 6 [Source:RGD Symbol;Acc:1307716] |
| Ensembl ID | ENSRNOG00000019771 |
| Bio databases IDs | |
| Aliases | T-box transcription factor 6 |
| Synonyms | rv, SCDO5, T-box 6, T-box transcription factor 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tbx6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- T-box
- double-stranded DNA binding
- nucleic acid binding
- transcription co-repressor
- DNA-binding domain of the T-box transcription factor family
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spondylocostal dysostosis type 5
- multiple sclerosis
- hereditary disorder
role in cell
- differentiation
- activation in
- development
- maturation by
- specification
- degeneration in
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tbx6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neuron maturation
- signal transduction involved in regulation of gene expression
- mesoderm development
- anatomical structure morphogenesis
- negative regulation of sequence-specific DNA binding transcription factor activity
- vasculogenesis
- positive regulation of transcription from RNA polymerase II promoter
- mesodermal cell fate specification
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron projection development
- heart looping
- cell fate specification
- somite rostral/caudal axis specification
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity