Mprip Gene Summary [Rat]
Predicted to enable actin filament binding activity. Involved in maintenance of protein location in cell and protein dephosphorylation. Located in stress fiber. Orthologous to human MPRIP (myosin phosphatase Rho interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mprip |
| Official Name | myosin phosphatase Rho interacting protein [Source:RGD Symbol;Acc:619947] |
| Ensembl ID | ENSRNOG00000003226 |
| Bio databases IDs | |
| Aliases | myosin phosphatase Rho interacting protein |
| Synonyms | 9530046C02, Gm34094, LOC100507087, mKIAA0864, M-RIP, myosin phosphatase Rho interacting protein, p116Rip, Rb109, RHOIP3, RIP3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mprip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Mitotic checkpoint protein
- Domain of unknown function (DUF4515)
- Ciliary protein causing Leber congenital amaurosis disease
- RhoA binding domain
- Yuri gagarin
- Domain of unknown function (DUF4618)
- helix-rich Mycoplasma protein
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
- Calcium binding and coiled-coil domain (CALCOCO1) like
- FlgN protein
- Cdc37 N terminal kinase binding
- Laminin Domain I
- Alpha helical coiled-coil rod protein (HCR)
- Family with sequence similarity 184, A and B
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- PH domain
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
- HOOK protein coiled-coil region
Pathways
Biological processes and signaling networks where the Mprip gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- Huntington disease
- atrial fibrillation
role in cell
- quantity
- apoptosis
- proliferation
- production in
- phosphorylation in
- cell spreading
- formation
- inhibition
- outgrowth
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- actin filaments
- cytosol
- cortical actin filaments
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mprip gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- cadherin binding