Rock1 Gene Summary [Rat]
Enables small GTPase binding activity. Involved in cytoskeleton organization; positive regulation of gene expression; and response to transforming growth factor beta. Acts upstream of or within Rho protein signal transduction. Is active in synapse. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rock1 |
| Official Name | Rho-associated coiled-coil containing protein kinase 1 [Source:RGD Symbol;Acc:620424] |
| Ensembl ID | ENSRNOG00000031092 |
| Bio databases IDs | |
| Aliases | Rho-associated coiled-coil containing protein kinase 1 |
| Synonyms | 1110055K06Rik, LOC100129157, P160ROCK, p160 ROCK-1, Rho-associated coiled-coil containing protein kinase 1, ROCK, ROCK-I, ROK, ROK beta, ROK β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rock1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p21 binding domain
- protein serine/threonine kinase
- Synaptonemal complex protein 1 (SCP-1)
- Rho Binding
- helix-rich Mycoplasma protein
- coiled-coil domain
- Protein kinase domain
- Extension to Ser/Thr-type protein kinases
- protein kinase C conserved region 1 (C1 domain) superfamily
- shroom2 binding domain
- Tyrosine kinase, catalytic domain
- HR1
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Protein kinase (unclassified specificity)
- enzyme binding
- protein binding
- Pleckstrin homology-like domain
- Calcium binding and coiled-coil domain (CALCOCO1) like
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Alpha helical coiled-coil rod protein (HCR)
- RIM-binding protein of the cytomatrix active zone
- Protein Kinases, catalytic domain
- Rho-binding domain
Pathways
Biological processes and signaling networks where the Rock1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Apoptosis Signaling
- CCR3 Signaling in Eosinophils
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Death Receptor Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Ephrin A Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Gα12/13 Signaling
- NGF Signaling
- PCP pathway
- PEDF Signaling
- Regulation of Actin-based Motility by Rho
- RhoA Signaling
- Semaphorin Signaling in Neurons
- Thrombin Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- organismal death
- cardiac hypertrophy
- prostate cancer
- omphalocele
- bladder cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- laryngeal squamous cell carcinoma
role in cell
- migration
- invasion by
- activation in
- expression in
- proliferation
- phosphorylation in
- apoptosis
- aggregation
- serine threonine phosphorylation in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- ruffle
- secretory granule lumen
- cytoskeleton
- Extracellular Space
- perinuclear region
- pericentriolar regions
- Plasma Membrane
- centrosome
- centriole
- Mitochondria
- intercellular junctions
- cytosol
- intercentriolar linker
- synapse
- early endosomes
- stress granule
- perikaryon
- plasma
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rock1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- regulation of stress fiber assembly
- negative regulation of protein binding
- cortical actin cytoskeleton organization
- motor neuron apoptotic process
- negative regulation of membrane protein ectodomain proteolysis
- positive regulation of cardiac muscle hypertrophy
- negative regulation of biomineral tissue development
- negative regulation of motor neuron apoptotic process
- regulation of establishment of cell polarity
- regulation of keratinocyte differentiation
- aortic valve morphogenesis
- actomyosin structure organization
- positive regulation of beta-amyloid clearance
- apical constriction
- Rho protein signal transduction
- positive regulation of autophagy
- regulation of focal adhesion assembly
- regulation of actin cytoskeleton organization
- positive regulation of focal adhesion assembly
- myoblast migration
- negative regulation of myosin-light-chain-phosphatase activity
- positive regulation of gene expression
- positive regulation of dephosphorylation
- epithelial to mesenchymal transition
- peptidyl-serine phosphorylation
- regulation of cell migration
- peptidyl-threonine phosphorylation
- protein localization in plasma membrane
- mRNA destabilization
- regulation of microtubule cytoskeleton organization
- regulation of neuron differentiation
- protein phosphorylation
- leukocyte cell-cell adhesion
- smooth muscle contraction
- cytokinesis after mitosis
- response to transforming growth factor beta stimulus
- regulation of synapse maturation
- bleb assembly
- neuron projection development
- signal transduction
- regulation of synaptic vesicle endocytosis
- positive regulation of MAPK cascade
- membrane to membrane docking
- I-kappaB kinase/NF-kappaB cascade
- negative regulation of phosphorylation
- positive regulation of phosphatase activity
- embryonic morphogenesis
- regulation of cell motility
- leukocyte migration
- leukocyte tethering or rolling
- regulation of cell adhesion
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- Golgi membrane
- extracellular region
- plasma membrane
- cytoskeleton
- centriole
- cytoplasm
- ruffle
- cytosol
- bleb
- secretory granule lumen
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- tau-protein kinase activity
- ATP binding
- protein binding
- metal ion binding
- tau protein binding
- small GTPase binding
- protein kinase activity
- Rho-dependent protein serine/threonine kinase activity
- protein serine/threonine kinase activity