Gcdh Gene Summary [Rat]
Enables fatty-acyl-CoA binding activity; flavin adenine dinucleotide binding activity; and glutaryl-CoA dehydrogenase activity. Involved in fatty acid oxidation and fatty-acyl-CoA biosynthetic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in glutaric acidemia I. Orthologous to human GCDH (glutaryl-CoA dehydrogenase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gcdh |
| Official Name | glutaryl-CoA dehydrogenase [Source:RGD Symbol;Acc:1308829] |
| Ensembl ID | ENSRNOG00000003307 |
| Bio databases IDs | |
| Aliases | glutaryl-CoA dehydrogenase |
| Synonyms | 9030411L18, ACAD5, GCD, GCDH isoform 1, glutaryl-CoA dehydrogenase, Glutaryl Coenzyme A Dehydrogenase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gcdh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- flavin adenine dinucleotide binding
- Acyl-CoA dehydrogenase, C-terminal domain
- acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, middle domain
- acyl-CoA binding
- enzyme
- glutaryl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, N-terminal domain
Pathways
Biological processes and signaling networks where the Gcdh gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- epithelial cancer
- cancer
- glutaric acidemia type 1
- non-insulin-dependent diabetes mellitus
- liver cancer
- organismal death
- insomnia
- hereditary disorder
- Pelizaeus-Merzbacher-like disease
role in cell
- signaling in
- cell death
- cell viability
- expression in
- upregulation in
- apoptosis
- transmembrane potential
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gcdh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty-acyl-CoA biosynthetic process
- fatty acid beta-oxidation using acyl-CoA dehydrogenase
- tryptophan metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- flavin adenine dinucleotide binding
- fatty-acyl-CoA binding
- glutaryl-CoA dehydrogenase activity