Fundc1 Gene Summary [Rat]
Predicted to be involved in mitochondrial fusion; mitophagy; and response to hypoxia. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human FUNDC1 (FUN14 domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fundc1 |
| Official Name | FUN14 domain containing 1 [Source:RGD Symbol;Acc:1563372] |
| Ensembl ID | ENSRNOG00000003470 |
| Bio databases IDs | |
| Aliases | FUN14 domain containing 1 |
| Synonyms | 1500005J14Rik, 1810033P05Rik, FUN14 domain containing 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fundc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LC3-interacting region
- FUN14 family
- protein binding
Pathways
Biological processes and signaling networks where the Fundc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- dilated cardiomyopathy
- Duchenne muscular dystrophy
role in cell
- expression in
- phosphorylation in
- binding in
- apoptosis
- contraction
- necroptosis
- formation
- formation in
- injury
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fundc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hypoxia
- macromitophagy
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding