Klk4 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in amelogenesis; extracellular matrix disassembly; and protein maturation. Predicted to act upstream of or within protein catabolic process. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A1 and prostate cancer. Orthologous to human KLK4 (kallikrein related peptidase 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klk4 |
| Official Name | kallikrein-related peptidase 4 [Source:RGD Symbol;Acc:1303228] |
| Ensembl ID | ENSRNOG00000018864 |
| Bio databases IDs | |
| Aliases | kallikrein-related peptidase 4 |
| Synonyms | AI2A1, ARM1, EMSP, EMSP1, ESMP1, kallikrein, kallikrein-related peptidase 4, kallikrein related-peptidase 4 (prostase, enamel matrix, prostate), KLK-L1, Klnb1, PRSS17, PSTS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
- protein binding
Pathways
Biological processes and signaling networks where the Klk4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypomaturation type amelogenesis imperfecta type IIA1
- hereditary angioedema
- colorectal adenoma
- colorectal adenoma formation
- psoriasis
- atopic dermatitis
- prostate cancer
- amelogenesis imperfecta
- epithelial cancer
- prostatic carcinoma
role in cell
- growth
- proliferation
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extracellular matrix disassembly
- proteolysis
- amelogenesis
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- serine-type endopeptidase activity
- serine-type peptidase activity