Ntf4 Gene Summary [Rat]
Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Predicted to be involved in several processes, including ameloblast differentiation; cell surface receptor signaling pathway; and nervous system development. Predicted to act upstream of or within negative regulation of programmed cell death; nervous system development; and taste bud development. Predicted to be located in extracellular region. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Orthologous to human NTF4 (neurotrophin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ntf4 |
| Official Name | neurotrophin 4 [Source:RGD Symbol;Acc:3212] |
| Ensembl ID | ENSRNOG00000020783 |
| Bio databases IDs | |
| Aliases | neurotrophin 4 |
| Synonyms | 2900040K06Rik, AI462899, GLC10, GLC1O, neurotrophin 4, Neurotrophin 5, NT-4, NT-4/5, NT4P, NT-5, NTF5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ntf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neurotrophin p75 receptor binding
- protein binding
- growth factor
- Nerve growth factor family
Pathways
Biological processes and signaling networks where the Ntf4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- rheumatoid arthritis
- heat hyperalgesia
- Alzheimer disease
- hereditary disorder
- atopic dermatitis
- open angle glaucoma type 1O
- colon epithelial cancer
- spondylarthritis
- colon adenocarcinoma
role in cell
- synthesis in
- expression in
- differentiation
- apoptosis
- migration
- cell death
- proliferation
- loss
- survival
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Golgi Apparatus
- endoplasmic reticulum lumen
- nerve ending
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ntf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory organ boundary specification
- innervation
- neuron projection morphogenesis
- epidermis development
- transmembrane receptor protein tyrosine kinase signaling pathway
- adult locomotory behavior
- nerve development
- negative regulation of neuron apoptotic process
- long-term memory
- mechanoreceptor differentiation
- regulation of synaptic transmission
- taste bud development
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- synaptic vesicle
- extracellular region
- axon
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- nerve growth factor receptor binding