Chrne Gene Summary [Rat]
Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 4A; congenital myasthenic syndrome 4B; and congenital myasthenic syndrome 4C. Orthologous to human CHRNE (cholinergic receptor nicotinic epsilon subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrne |
| Official Name | cholinergic receptor nicotinic epsilon subunit [Source:RGD Symbol;Acc:2353] |
| Ensembl ID | ENSRNOG00000003777 |
| Bio databases IDs | |
| Aliases | cholinergic receptor nicotinic epsilon subunit |
| Synonyms | ACHRE, AChrepsilon, AChR ε, Acre, Cholinergic receptor, nicotinic, epsilon polypeptide, cholinergic receptor nicotinic epsilon subunit, Cholinergic receptor, nicotinic, ε polypeptide, cholinergic receptor nicotinic ε subunit, CMS1A1, CMS1D, CMS1E, CMS2A, CMS4A, CMS4B, CMS4C, FCCMS, FIM1, FIMG, FIMG1, MGI, nAChR, nAChRE, nAChR ε, SCCMS, ε AChR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chrne often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- pore domain
- cation transporter
- acetylcholine receptor
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- transmembrane receptor
- agonist binding domain
- cation channel
Pathways
Biological processes and signaling networks where the Chrne gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- Wtx1
- NXPE3
- cisatracurium
- D-tubocurarine
- mivacurium
- succinylcholine
- rapacuronium
- isoflurane
- pipecuronium
- metocurine
disease
- Alzheimer disease
- schizophrenia
- schizoaffective disorder
- major depression
- morbid obesity
- non-insulin-dependent diabetes mellitus
- congenital myasthenic syndrome
- fast-channel congenital myasthenic syndrome 4B
- congenital myasthenic syndrome associated with acetylcholine receptor deficiency type 4C
- familial infantile myasthenia type 1
role in cell
- development
- abnormal morphology
- morphology
- transmembrane potential
- sprouting
- gating in
- synaptic transmission
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- neuromuscular junctions
- motor endplates
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chrne gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- regulation of excitatory postsynaptic membrane potential
- signal transduction
- muscle contraction
- ion transmembrane transport
- synaptic transmission
- membrane depolarization
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- neuromuscular junction
- synapse
- acetylcholine-gated channel complex
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- acetylcholine receptor activity
- acetylcholine-gated cation channel activity
- cation transmembrane transporter activity