Crlf1 Gene Summary [Rat]
Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor binding activity and cytokine activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of motor neuron apoptotic process; and ureteric bud development. Predicted to be part of CRLF-CLCF1 complex and receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 1. Orthologous to human CRLF1 (cytokine receptor like factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crlf1 |
| Official Name | cytokine receptor-like factor 1 [Source:RGD Symbol;Acc:1311371] |
| Ensembl ID | ENSRNOG00000020030 |
| Bio databases IDs | |
| Aliases | cytokine receptor-like factor 1 |
| Synonyms | CISS, CISS1, CLF, CLF-1, CRLM-3, Cytokine receptor-like factor 1, NR6, NR6.1, ZCYTOR5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crlf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ig-like C2-type domain
- cytokine binding
- ciliary neurotrophic factor receptor binding
- FN3
- Obesity receptor immunoglobulin like domain
- Purple acid Phosphatase, N-terminal domain
- protein binding
- Fibronectin type 3 domain
- Interferon-alpha/beta receptor, fibronectin type III
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cold-induced sweating syndrome 1
- hypothermia-sweating syndrome
- mouth mucosal ulcer
- diabetic nephropathy
- androgenic alopecia
- Crisponi/cold-induced sweating syndrome
- cone-rod dystrophy type 12
- hereditary disorder
- idiopathic pulmonary fibrosis
role in cell
- expression in
- quantity
- phosphorylation in
- number
- proliferation
- apoptosis
- production in
- response
- survival
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crlf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ureteric bud development
- cytokine-mediated signaling pathway
- positive regulation of cell proliferation
- positive regulation of tyrosine phosphorylation of STAT protein
- negative regulation of motor neuron apoptotic process
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- CRLF-CLCF1 complex
- external side of plasma membrane
- cytosol
- receptor complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity
- cytokine binding
- ciliary neurotrophic factor receptor binding
- cytokine receptor activity