Scin Gene Summary [Rat]
Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin polymerization or depolymerization; positive regulation of megakaryocyte differentiation; and regulation of actin filament organization. Part of protein-containing complex. Orthologous to human SCIN (scinderin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scin |
| Official Name | scinderin [Source:RGD Symbol;Acc:735034] |
| Ensembl ID | ENSRNOG00000004498 |
| Bio databases IDs | |
| Aliases | scinderin |
| Synonyms | adseverin, Scind, Scinderin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scin often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scinderin domain
- actin filament binding
- phospholipid binding
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- actin-binding domain
- binding protein
- Gelsolin repeat
- phosphatidylinositol-4,5-bisphosphate binding
- actin binding
- calcium ion binding
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic scoliosis
- acute graft-vs-host disease
- Modic changes
- small cell lung carcinoma
- small cell lung cancer
role in cell
- migration
- quantity
- proliferation
- apoptosis
- invasion by
- differentiation
- bending
- volume
- polyploidization
- resorption by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell cortex
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scin gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sequestering of actin monomers
- regulation of chondrocyte differentiation
- actin polymerization or depolymerization
- cell projection assembly
- negative regulation of cell proliferation
- positive regulation of megakaryocyte differentiation
- barbed-end actin filament capping
- positive regulation of secretion
- central nervous system development
- actin filament severing
- actin filament capping
- actin nucleation
- positive regulation of apoptotic process
- calcium ion-dependent exocytosis
- positive regulation of actin nucleation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- anchoring junction
- brush border
- cytoplasm
- cell cortex
- actin cytoskeleton
- cell projection
- podosome
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol-4,5-bisphosphate binding
- phosphatidylserine binding
- actin binding
- calcium ion binding
- 1-phosphatidylinositol binding