Hao1 Gene Summary [Rat]
Predicted to enable (S)-2-hydroxy-acid oxidase activity; FMN binding activity; and glyoxylate oxidase activity. Involved in response to oxidative stress. Located in peroxisome. Orthologous to human HAO1 (hydroxyacid oxidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hao1 |
| Official Name | hydroxyacid oxidase 1 [Source:RGD Symbol;Acc:1589750] |
| Ensembl ID | ENSRNOG00000004601 |
| Bio databases IDs | |
| Aliases | hydroxyacid oxidase 1 |
| Synonyms | GLUCOSE OXIDASE, GO, GOX, GOX1, HAOX1, hydroxyacid oxidase 1, hydroxyacid oxidase 1, liver, XDH1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hao1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TIM-like beta/alpha barrel domains
- FMN binding
- (S)-2-hydroxy-acid oxidase
- FMN-dependent dehydrogenase
- enzyme
- glyoxylate oxidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- calcium oxalate nephrolithiasis
- primary hyperoxaluria type I
- streptozotocin induced type1 diabetes
- hepatitis B virus-related hepatocellular carcinoma
- primary hyperoxaluria
role in cell
- expression in
- proliferation
- recruitment
- interaction in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- intracellular membrane-bounded organelle
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hao1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycolate catabolic process
- response to oxidative stress
- glycine biosynthetic process
- fatty acid alpha-oxidation
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- (S)-2-hydroxy-acid oxidase activity
- FMN binding
- glyoxylate oxidase activity