Il20 Gene Summary [Rat]
Predicted to enable cytokine activity; interleukin-20 receptor binding activity; and interleukin-22 receptor binding activity. Predicted to be involved in immune response and positive regulation of signaling receptor activity. Predicted to act upstream of or within positive regulation of osteoclast differentiation. Predicted to be active in extracellular space. Biomarker of end stage renal disease. Human ortholog(s) of this gene implicated in psoriasis. Orthologous to human IL20 (interleukin 20). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il20 |
| Official Name | interleukin 20 [Source:RGD Symbol;Acc:1583578] |
| Ensembl ID | ENSRNOG00000004633 |
| Bio databases IDs | |
| Aliases | interleukin 20 |
| Synonyms | If2d, IL10D, interleukin 20, LOC681692, ZCYTO10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-20 receptor binding
- protein binding
- cytokine
- interleukin-22 receptor binding
Pathways
Biological processes and signaling networks where the Il20 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- mouth mucosal ulcer
- organismal death
- delayed hypersensitive reaction
- psoriasis
- atopic dermatitis
- pruritus
- osteoporosis
- arthritis
- osteopenia
role in cell
- production in
- expression in
- upregulation in
- migration
- proliferation
- osteoclastogenesis
- colony formation by
- differentiation
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte differentiation
- osteoclast differentiation
- positive regulation of epidermal cell differentiation
- positive regulation of osteoclast differentiation
- signal transduction
- regulation of inflammatory response
- positive regulation of tyrosine phosphorylation of STAT protein
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interleukin-20 receptor binding
- interleukin-22 receptor binding
- cytokine activity