Porcn Gene Summary [Rat]
Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Predicted to be involved in several processes, including Wnt protein secretion; Wnt signaling pathway; and protein palmitoleylation. Predicted to act upstream of or within glycoprotein metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in endoplasmic reticulum; glutamatergic synapse; and membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (porcupine O-acyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Porcn |
| Official Name | porcupine O-acyltransferase [Source:RGD Symbol;Acc:1564947] |
| Ensembl ID | ENSRNOG00000004819 |
| Bio databases IDs | |
| Aliases | porcupine O-acyltransferase |
| Synonyms | 2410004O13Rik, DHOF, DXHXS7465e, FODH, MG61, mMg61, Mporc, PORC, porcupine O-acyltransferase, PPN, RGD1564947 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Porcn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Wnt-protein binding
- enzyme
- protein binding
- O-acyltransferase
- Non-amino-acyl group acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- hyperplasia
- focal dermal hypoplasia
- hereditary disorder
- global developmental delay
- syndactyly
- coloboma
- lung cancer
- tumorigenesis
role in cell
- apoptosis
- proliferation
- expansion
- motility
- downregulation in
- signaling in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Porcn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Wnt protein secretion
- glycoprotein metabolic process
- protein lipidation
- Wnt receptor signaling pathway
- protein palmitoylation
- protein palmitoleylation
- lipid modification
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- Wnt-protein binding