Rgr Gene Summary [Rat]
Predicted to enable G protein-coupled photoreceptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; cellular response to light stimulus; and phototransduction. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 44. Orthologous to human RGR (retinal G protein coupled receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgr |
| Official Name | retinal G protein coupled receptor [Source:RGD Symbol;Acc:1309174] |
| Ensembl ID | ENSRNOG00000012396 |
| Bio databases IDs | |
| Aliases | retinal G protein coupled receptor |
| Synonyms | retinal G protein coupled receptor, RP44 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rgr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Rgr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa
- retinitis pigmentosa type 44
- myopia
- hyperopia
- ophthalmic disorder
- retinal dystrophy
- rhabdomyosarcoma
- soft tissue sarcoma cancer
- arteriosclerosis
- depigmentation
regulated by
- RXRA
- Z-LLL-CHO
- zeaxanthin dipalmitate
role in cell
- apoptosis
- expression in
- proliferation
- cell death
- growth
- cisplatin sensitivity
- mobilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rgr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to light stimulus
- G-protein coupled receptor signaling pathway
- detection of visible light
- visual perception
- phototransduction
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- G-protein coupled photoreceptor activity