Loxl1 Gene Summary [Rat]
Predicted to enable protein-lysine 6-oxidase activity. Involved in aorta development and response to lipopolysaccharide. Located in acrosomal vesicle and basement membrane. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; exfoliation syndrome; and primary open angle glaucoma. Orthologous to human LOXL1 (lysyl oxidase like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Loxl1 |
| Official Name | lysyl oxidase-like 1 [Source:RGD Symbol;Acc:1308752] |
| Ensembl ID | ENSRNOG00000008680 |
| Bio databases IDs | |
| Aliases | lysyl oxidase-like 1 |
| Synonyms | LOC103689962, LOL, LOXL, lysyl oxidase-like 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loxl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- protein-lysine 6-oxidase
- enzyme
- protein binding
- Lysyl oxidase
- pro domain
- CH-NH2 group:oxygen oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myocardial infarction
- rheumatoid arthritis
- cutaneous sarcoidosis
- uterine prolapse
- refractive error
- rectal prolapse
- coronary artery disease
- exfoliative glaucoma
- Duchenne muscular dystrophy
- abdominal aortic aneurysm
role in cell
- expression in
- phosphorylation in
- tumorigenicity
- abnormal morphology
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- acrosome
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loxl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aorta development
- protein deamination
- peptidyl-lysine oxidation
- response to lipopolysaccharide
- collagen fibril organization
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular space
- acrosomal vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- copper ion binding
- protein-lysine 6-oxidase activity