Pdyn Gene Summary [Rat]
Predicted to enable opioid receptor binding activity. Involved in response to immobilization stress and response to nicotine. Located in several cellular components, including dendritic spine; dense core granule; and neuronal cell body. Is active in neuronal dense core vesicle lumen and synaptic vesicle. Used to study depressive disorder. Biomarker of several diseases, including alcohol use disorder; amphetamine abuse; brain disease (multiple); cocaine abuse; and morphine dependence. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; amphetamine abuse; drug dependence (multiple); and spinocerebellar ataxia type 23. Orthologous to human PDYN (prodynorphin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdyn |
| Official Name | prodynorphin [Source:RGD Symbol;Acc:62054] |
| Ensembl ID | ENSRNOG00000026036 |
| Bio databases IDs | |
| Aliases | prodynorphin |
| Synonyms | ADCA, alpha NEOENDORPHIN, Dyn, DYNORPHIN, DYNORPHIN A, DYNORPHIN B, [Leu5]-enkephalin, PENKB, prodynorphin, Proenkephalin B, SCA23, α NEOENDORPHIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdyn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vertebrate endogenous opioids neuropeptide
- protein binding
- neuropeptide hormone
- transporter
Pathways
Biological processes and signaling networks where the Pdyn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- spinocerebellar ataxia type 23
- insulin-dependent diabetes mellitus
- major depression
- hypertension
- bipolar disorder
- Parkinson disease
- atopic dermatitis
- depressive disorder
- Tourette syndrome
role in cell
- expression in
- apoptosis
- downregulation in
- activity
- firing
- ubiquitination in
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- secretory granule lumen
- cell surface
- Plasma Membrane
- Golgi Apparatus
- dendritic spines
- synaptic vesicles
- neurites
- synapse
- secretory vesicles
- secretory granules
- perikaryon
- axon terminals
- mossy fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdyn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- synaptic transmission
- sensory perception
Cellular Component
Where in the cell the gene product is active
- dendrite
- neuronal cell body
- extracellular region
- plasma membrane
- axon terminus
Molecular Function
What the gene product does at the molecular level
- opioid receptor binding
- opioid peptide activity