Hoxa1 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in several processes, including abducens nerve formation; embryonic organ morphogenesis; and optokinetic behavior. Predicted to act upstream of or within several processes, including cellular response to ethanol; cellular response to retinoic acid; and nervous system development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Athabaskan brainstem dysgenesis syndrome and autistic disorder. Orthologous to human HOXA1 (homeobox A1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxa1 |
| Official Name | homeobox A1 [Source:RGD Symbol;Acc:11414885] |
| Ensembl ID | ENSRNOG00000005628 |
| Bio databases IDs | |
| Aliases | homeobox A1 |
| Synonyms | BSAS, ERA1, homeobox A1, HOX1, Hox-1.6, HOX1F, Hoxa1l, LOC100911406, NEWGENE 2812 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- basic tetrad
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- identical protein binding
Pathways
Biological processes and signaling networks where the Hoxa1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- glioblastoma cancer
- Athabaskan brainstem dysgenesis syndrome
- neoplastic cell transformation
- leukemia
- anoxia
- respiratory failure
- glossopharyngeal-vagus nerve fusion
- early missed abortion
- muscle spasm
role in cell
- quantity
- expression in
- apoptosis
- growth
- proliferation
- differentiation
- migration
- development
- invasion
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hoxa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- cochlea development
- cochlea morphogenesis
- neuromuscular process
- embryonic neurocranium morphogenesis
- abducens nerve formation
- outer ear morphogenesis
- artery morphogenesis
- anatomical structure morphogenesis
- optokinetic behavior
- positive regulation of transcription from RNA polymerase II promoter
- artery development
- semicircular canal formation
- regulation of transcription from RNA polymerase II promoter
- regulation of behavior
- sensory perception of sound
- cognition
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity