Sostdc1 Gene Summary [Rat]
Predicted to enable BMP binding activity and BMP receptor activity. Predicted to be involved in negative regulation of determination of dorsal identity; negative regulation of myoblast differentiation; and negative regulation of signal transduction. Predicted to act upstream of or within several processes, including morphogenesis of an epithelium; negative regulation of canonical Wnt signaling pathway; and odontogenesis of dentin-containing tooth. Predicted to be active in extracellular space. Orthologous to human SOSTDC1 (sclerostin domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sostdc1 |
| Official Name | sclerostin domain containing 1 [Source:RGD Symbol;Acc:628877] |
| Ensembl ID | ENSRNOG00000005770 |
| Bio databases IDs | |
| Aliases | sclerostin domain containing 1 |
| Synonyms | 0610006G05Rik, CDA019, DAND7, ECTODIN, sclerostin domain containing 1, Sostl, USAG-1, Wise |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sostdc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycoprotein hormone beta chain homologues
- cytokine binding
- protein binding
- growth factor
- DAN domain
Pathways
Biological processes and signaling networks where the Sostdc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- schizophrenia
- breast cancer
- idiopathic pulmonary fibrosis
- androgenic alopecia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
role in cell
- phosphorylation in
- expression in
- invasion by
- differentiation
- number
- function
- commitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sostdc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pattern specification process
- odontogenesis of dentin-containing tooth
- mammary gland bud morphogenesis
- negative regulation of BMP signaling pathway
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of myoblast differentiation
- BMP signaling pathway
- hair follicle morphogenesis
- canonical Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- epithelial cell fate commitment
- negative regulation of determination of dorsal identity
- negative regulation of cell fate commitment
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- BMP binding