Mtmr2 Gene Summary [Rat]
Predicted to enable identical protein binding activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; and phosphatidylinositol-3-phosphate phosphatase activity. Involved in several processes, including dendritic spine maintenance; negative regulation of excitatory postsynaptic potential; and regulation of vesicle-mediated transport. Located in several cellular components, including dendritic spine; postsynaptic density; and synaptic vesicle. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B1. Orthologous to human MTMR2 (myotubularin related protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtmr2 |
| Official Name | myotubularin related protein 2 [Source:RGD Symbol;Acc:1311865] |
| Ensembl ID | ENSRNOG00000005923 |
| Bio databases IDs | |
| Aliases | myotubularin related protein 2 |
| Synonyms | 6030445P13Rik, CMT4B, CMT4B1, Mtmr2 predicted, myotubularin related protein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mtmr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol-3-phosphatase
- phosphatase
- Myotubularin-like phosphatase domain
- coiled-coil domain
- PTP_DSP_cys
- protein binding
- Pleckstrin homology-like domain
- phosphatase domain
- PDZ binding motif
- identical protein binding
Pathways
Biological processes and signaling networks where the Mtmr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- Charcot-Marie-Tooth disease type 4
- Charcot-Marie-Tooth disease type 4b1
- Alzheimer disease
- neuropathy
- demyelinating hereditary motor and sensory neuropathy
- tremor
- gait disturbance
- azoospermia
- chronic lymphocytic leukemia
role in cell
- quantity
- maintenance
- assembly
- development
- function
- density
- myelination
- accumulation in
- function in
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- early endosomal fractions
- extrasynaptic compartment
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- vacuole
- cytosol
- synaptic membrane
- dendritic spines
- synaptic vesicles
- synaptosomes
- axons
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mtmr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endocytosis
- negative regulation of receptor internalization
- protein dephosphorylation
- neuron development
- phosphatidylinositol biosynthetic process
- negative regulation of excitatory postsynaptic membrane potential
- dendritic spine maintenance
- regulation of phosphatidylinositol dephosphorylation
- phosphatidylinositol dephosphorylation
- positive regulation of early endosome to late endosome transport
- myelin assembly
- negative regulation of receptor catabolic process
- negative regulation of myelination
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- synaptic vesicle
- synaptic membrane
- vacuolar membrane
- early endosome membrane
- nucleus
- dendrite
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- dendritic spine
- membrane
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- phosphatidylinositol-3-phosphatase activity
- protein binding
- phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity