Cpq Gene Summary [Rat]
Predicted to enable metallodipeptidase activity and protein homodimerization activity. Involved in proteolysis; thyroid hormone generation; and tissue regeneration. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and lysosome. Orthologous to human CPQ (carboxypeptidase Q). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpq |
| Official Name | carboxypeptidase Q [Source:RGD Symbol;Acc:628610] |
| Ensembl ID | ENSRNOG00000005931 |
| Bio databases IDs | |
| Aliases | carboxypeptidase Q |
| Synonyms | 1190003P12Rik, 2610034C17RIK, carboxypeptidase Q, Hls2, LAL, Lal-1, LDP, PGCP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PA domain
- Zinc peptidases M18, M20, M28, and M42
- metalloexopeptidase
- PA
- dipeptidase
- peptidase
- protein homodimerization
- Peptidase family M28
Pathways
Biological processes and signaling networks where the Cpq gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- attention deficit hyperactivity disorder
- Epstein-Barr virus infection
- opioid dependence
- papillary renal cell carcinoma
- papillary renal cell neoplasia
- renal cell cancer
- breast cancer
- autosomal dominant Emery-Dreifuss muscular dystrophy
- Duchenne muscular dystrophy
regulates
- peptide
- thyroid hormone
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular membrane-bounded organelle
- Cytoplasm
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide catabolic process
- thyroid hormone generation
- proteolysis
- tissue regeneration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- endoplasmic reticulum
- Golgi apparatus
- lysosome
Molecular Function
What the gene product does at the molecular level
- carboxypeptidase activity
- protein homodimerization activity
- metallodipeptidase activity
- metal ion binding