Ptprz1 Gene Summary [Rat]
Enables fibroblast growth factor binding activity and protein tyrosine phosphatase activity. Involved in several processes, including nervous system development; positive regulation of cell migration; and regulation of dendrite development. Located in several cellular components, including perineuronal net; postsynaptic membrane; and ruffle membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of amyotrophic lateral sclerosis; middle cerebral artery infarction; status epilepticus; and temporal lobe epilepsy. Orthologous to human PTPRZ1 (protein tyrosine phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptprz1 |
| Official Name | protein tyrosine phosphatase, receptor type Z1 [Source:RGD Symbol;Acc:3455] |
| Ensembl ID | ENSRNOG00000006030 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type Z1 |
| Synonyms | DSD-1-PG, HPTPZ, HPTPzeta, Phosphacan, protein tyrosine phosphatase receptor type Z1, protein tyrosine phosphatase, receptor type Z1, protein tyrosine phosphatase receptor type Z, polypeptide 1, PTP18, PTPbeta, PTPRZ, PTPZ, PTPZ1 isoform 1, PTP-ZETA, PTP-ZETA-A, PTPzeta-B, PTPzeta-S, PTP-ζ, PTP-ζ-A, RPTPB, RPTPbeta, RPTP beta/zeta, RPTPz, RPTP-ZETA, R-PTP-zeta-2, Rptp zeta/beta, RPTP β/ζ, RPTP-ζ, R-PTP-ζ-2, Rptp ζ/β |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptprz1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein-tyrosine-phoshatase
- catalytic domain
- carbonic anhydrase domain
- Protein tyrosine phosphatase, catalytic domain
- alpha_CA
- Fibronectin type 3 domain
- PTP_DSP_cys
- protein binding
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- fibroblast growth factor binding
- transmembrane receptor protein tyrosine phosphatase
- FN3
- spacer domain
- Eukaryotic-type carbonic anhydrase
- integrin binding
- phosphatase
- active site
- intracellular domain
Pathways
Biological processes and signaling networks where the Ptprz1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung metastasis
- cancer
- Alzheimer disease
- experimental autoimmune encephalomyelitis
- Waldenström macroglobulinemia
- hypocalcemia
- osteosarcomagenesis
- ovarian carcinoma
- epithelial ovarian cancer
role in cell
- expression in
- differentiation
- proliferation
- phosphorylation in
- apoptosis
- activation in
- quantity
- myelination
- migration
- clonogenicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- soluble fraction
- glutaminergic synapse
- intracellular compartment
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- cellular membrane
- Nucleus
- membrane ruffles
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- growth cone
- synapse
- cytoplasmic vesicles
- extracellular matrix
- filopodia
- perikaryon
- axons
- dendrites
- dendritic shafts
- perineuronal net
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptprz1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- central nervous system development
- axonogenesis
- protein dephosphorylation
- regulation of oligodendrocyte progenitor proliferation
- regulation of myelination
- peptidyl-tyrosine dephosphorylation
- hemopoietic progenitor cell differentiation
- negative regulation of neuron apoptotic process
- learning or memory
- positive regulation of oligodendrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- perineuronal net
- synapse
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity
- integrin binding
- transmembrane receptor protein tyrosine phosphatase activity