Uba3 Gene Summary [Rat]
Enables NEDD8 activating enzyme activity and nuclear receptor binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uba3 |
| Official Name | ubiquitin-like modifier activating enzyme 3 [Source:RGD Symbol;Acc:621084] |
| Ensembl ID | ENSRNOG00000006221 |
| Bio databases IDs | |
| Aliases | ubiquitin-like modifier activating enzyme 3 |
| Synonyms | A830034N06RIK, hUBA3, NAE1, NAE2, UBE1C, ubiquitin-like modifier activating enzyme 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Uba3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NEDD8 ligase
- ligand-dependent nuclear receptor interactor
- binding protein
- RUB1 activating enzyme
- Ubiquitin/SUMO-activating enzyme ubiquitin-like domain
- enzyme
- protein binding
- E1_enzyme_family
- identical protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- monoclonal gammopathy of undertermined significance
- hepatic steatosis
- plasma cell myeloma
- lung adenocarcinoma
- lung adenocarcinoma formation
- lung cancer
- pneumonitis
role in cell
- phosphorylation in
- expression in
- production in
- migration
- proliferation
- cell death
- apoptosis
- S phase
- cell cycle progression
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Uba3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- proteolysis
- endomitotic cell cycle
- protein neddylation
- regulation of cell cycle
- post-translational protein modification
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- protein heterodimerization activity
- NEDD8 activating enzyme activity
- NEDD8 ligase activity