Map3k20 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; JUN kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including cellular response to radiation; intracellular signal transduction; and regulation of cellular response to stress. Predicted to act upstream of with a positive effect on pyroptotic inflammatory response. Predicted to act upstream of or within cytoskeleton organization. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map3k20 |
| Official Name | mitogen-activated protein kinase kinase kinase 20 [Source:RGD Symbol;Acc:1561394] |
| Ensembl ID | ENSRNOG00000001515 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 20 |
| Synonyms | AZK, B230120H23Rik, CNM6, HCCS-4, mitogen-activated protein kinase kinase kinase 20, MLK7, mlklak, MLT, MLTK, MLTK alpha, MLTKbeta, MLTK α, MRK, pk, RGD1561394, SFMMP, ZAK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Map3k20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- rRNA binding
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- ATP binding
- JUN kinase kinase kinase
- protein kinase regulator
- protein binding
- magnesium ion binding
- Protein kinase domain
- MAP kinase kinase kinase
- kinase
- protein kinase activator
- Serine/Threonine protein kinases, catalytic domain
- Sterile alpha motif
- Protein Kinases, catalytic domain
- ribosome binding
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Map3k20 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- split-foot malformation with mesoaxial polydactyly
- androgenic alopecia
- Alzheimer disease
- centronuclear myopathy 6 with fiber-type disproportion
- dermatitis
- colorectal adenoma
- colorectal adenoma formation
- dementia
- colorectal carcinomagenesis
- abdominal aortic aneurysm
role in cell
- expression in
- invasion
- phosphorylation in
- activation in
- migration
- cellular infiltration by
- quantity
- invasion by
- apoptosis
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Map3k20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- cytoskeleton organization
- p38MAPK cascade
- limb development
- stress-activated protein kinase signaling cascade
- positive regulation of programmed cell death
- protein autophosphorylation
- chromosome segregation
- JNK cascade
- protein phosphorylation
- embryonic digit morphogenesis
- cellular response to UV-B
- MAPK cascade
- DNA damage checkpoint
- cellular response to gamma radiation
- inflammatory response
- cell death
- positive regulation of apoptotic process
- cell differentiation
- pyroptosis
- peptidyl-serine phosphorylation
- stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- RNA binding
- protein binding
- protein kinase activator activity
- JUN kinase kinase kinase activity
- ribosome binding
- MAP kinase kinase kinase activity
- protein serine/threonine kinase activity
- SSU rRNA binding