Il24 Gene Summary [Rat]
Predicted to enable cytokine activity. Involved in several processes, including cellular response to interleukin-4; cellular response to lipopolysaccharide; and serine phosphorylation of STAT protein. Located in extracellular space. Biomarker of periodontal disease. Orthologous to human IL24 (interleukin 24). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il24 |
| Official Name | interleukin 24 [Source:RGD Symbol;Acc:621484] |
| Ensembl ID | ENSRNOG00000004470 |
| Bio databases IDs | |
| Aliases | interleukin 24 |
| Synonyms | C49A, FISP, If2e, IL10B, interleukin 24, MDA7, MOB5, ST16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- secretion/acylation domain
- signal peptide
- protein binding
- cytokine
- Interleukin 10
Pathways
Biological processes and signaling networks where the Il24 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- plaque psoriasis
- psoriasis
- metastatic melanoma
- metastatic melanoma cancer
- chronic kidney disease
- psoriasis like inflammation
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- expression in
- number
- proliferation
- differentiation
- cell death
- binding in
- apoptosis
- transactivation in
- growth
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il24 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to lipopolysaccharide
- signal transduction
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- cellular response to interleukin-4
- apoptotic process
- positive regulation of tyrosine phosphorylation of STAT protein
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine activity