Rnpep Gene Summary [Rat]
Enables metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Involved in negative regulation of blood pressure; protein processing; and retina development in camera-type eye. Located in external side of plasma membrane; extracellular space; and secretory granule. Used to study hypertension. Biomarker of hypertension. Orthologous to human RNPEP (arginyl aminopeptidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnpep |
| Official Name | arginyl aminopeptidase [Source:RGD Symbol;Acc:621137] |
| Ensembl ID | ENSRNOG00000006720 |
| Bio databases IDs | |
| Aliases | arginyl aminopeptidase |
| Synonyms | Aminopeptidase B, Ap-B, arginyl aminopeptidase, arginyl aminopeptidase (aminopeptidase B) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rnpep often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- Peptidase family M1 domain
- metalloexopeptidase
- peptidase
- Leukotriene A4 hydrolase, C-terminal
- transition metal ion binding
- Peptidase M1 N-terminal domain
- copper ion binding
- zinc ion binding
- leukotriene A-4 hydrolase/aminopeptidase
- aminopeptidase
- peptidase GluZincin family
- arginyl aminopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Plasma Membrane
- vesicles
- plasma membrane extracellular face
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rnpep gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloexopeptidase activity
- metalloaminopeptidase activity
- aminopeptidase activity
- epoxide hydrolase activity