Septin2 Gene Summary [Rat]
Predicted to enable several functions, including GTPase activity; enzyme regulator activity; and identical protein binding activity. Involved in neuron projection development. Located in perinuclear region of cytoplasm. Part of exocyst. Is active in presynapse. Orthologous to human SEPTIN2 (septin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin2 |
| Official Name | septin 2 [Source:RGD Symbol;Acc:620056] |
| Ensembl ID | ENSRNOG00000017952 |
| Bio databases IDs | |
| Aliases | septin 2 |
| Synonyms | DIFF6, hNedd5, mKIAA0158, NEDD-5, Pnutl3, SEPT2, Vesp11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Septin2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase
- enzyme
- protein binding
- enzyme regulator activity
- identical protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- insulin-dependent diabetes mellitus
- prostatic carcinoma
- prostate cancer
- early onset hypertension
- male pattern hair loss
- cleft lip
role in cell
- apoptosis
- migration
- number
- growth
- fragmentation
- assembly
- colony formation by
- invasion by
- cell abscission in
- fragmentation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- membrane fraction
- mitochondrial fission sites
- microtubule cytoskeleton
- ciliary transition zone
- sperm annulus
- non-motile cilium
- presynaptic regions
- cilia
- cell surface
- perinuclear region
- actin cytoskeleton
- cell cortex
- Nucleus
- Plasma Membrane
- vesicles
- axonemes
- contractile rings
- actin filaments
- midbody
- cytoplasmic bridges
- connecting cilia
- nucleoplasm
- spindle fibers
- growth cone
- neurites
- synaptosomes
- synapse
- cleavage furrow
- cellular protrusions
- central spindle
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Septin2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- spermatogenesis
- cell differentiation
- protein localization
- smoothened signaling pathway
- regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- microtubule cytoskeleton
- cell division site
- cleavage furrow
- synaptic vesicle
- kinetochore
- axoneme
- plasma membrane
- septin ring
- nucleoplasm
- nucleus
- intercellular bridge
- extracellular vesicular exosome
- cytoplasm
- cell cortex
- sperm annulus
- spindle
- actin cytoskeleton
- cilium membrane
- midbody
- septin complex
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- cadherin binding
- binding, bridging