Tmtc3 Gene Summary [Rat]
Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in positive regulation of proteasomal protein catabolic process; protein O-linked mannosylation; and response to endoplasmic reticulum stress. Predicted to act upstream of or within several processes, including lung development; muscle cell development; and post-embryonic development. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in lissencephaly 8. Orthologous to human TMTC3 (transmembrane O-mannosyltransferase targeting cadherins 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmtc3 |
| Official Name | transmembrane O-mannosyltransferase targeting cadherins 3 [Source:RGD Symbol;Acc:1306351] |
| Ensembl ID | ENSRNOG00000006749 |
| Bio databases IDs | |
| Aliases | transmembrane O-mannosyltransferase targeting cadherins 3 |
| Synonyms | 9130014E20RIK, B130008E12Rik, LIS8, mSmile, RGD1306351, SMILE, transmembrane and tetratricopeptide repeat containing 3, transmembrane O-mannosyltransferase targeting cadherins 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tmtc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- Assembly chaperone of ribosomal protein L4 and similar proteins
- Tetratricopeptide repeats
- type IV pilus biogenesis/stability protein PilW
- Protein O-mannosyl-transferase TMTC, DUF1736
- enzyme
- protein binding
- tetratricopeptide repeat
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- lissencephaly type 8
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- head and neck squamous cell cancer
- head and neck squamous cell carcinoma
role in cell
- phosphorylation in
- expression in
- production in
- proliferation
- migration
- invasion by
- development
- differentiation
- binding in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tmtc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked mannosylation
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- mannosyltransferase activity
- dolichyl-phosphate-mannose-protein mannosyltransferase activity