Fam3c Gene Summary [Rat]
Predicted to enable cytokine activity. Predicted to act upstream of or within several processes, including intracellular signaling cassette; keratinocyte proliferation; and neutrophil differentiation. Predicted to be located in Golgi apparatus. Predicted to be active in extracellular space. Orthologous to human FAM3C (FAM3 metabolism regulating signaling molecule C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam3c |
| Official Name | family with sequence similarity 3, member C [Source:RGD Symbol;Acc:735193] |
| Ensembl ID | ENSRNOG00000060349 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 3, member C |
| Synonyms | CANCELLOUS BONE OSTEOBLAST, D6Wsu176e, DNA segment chr6 wayne state university 176, FAM3 metabolism regulating signaling molecule C, GS3786, ILEI, PREDICTED OSTEOBLAST |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fam3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interleukin-like EMT inducer
- protein binding
- cytokine
- Domains similar to the Pancreatic-derived factor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- psoriasis
- neoplasia
- fibrosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- Alzheimer disease
- chronic obstructive pulmonary disease
- Huntington disease
- metastasis
role in cell
- expression in
- apoptosis
- differentiation
- binding in
- proliferation
- migration
- survival
- invasion by
- transactivation in
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- interchromatin granule cluster fractions
- secretory granule lumen
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fam3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- Golgi apparatus
- platelet dense granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- carbohydrate binding
- cytokine activity