Cdk14 Gene Summary [Rat]
Predicted to enable cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in G2/M transition of mitotic cell cycle; regulation of canonical Wnt signaling pathway; and regulation of cell cycle phase transition. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytosol and nucleus. Orthologous to human CDK14 (cyclin dependent kinase 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk14 |
| Official Name | cyclin-dependent kinase 14 [Source:RGD Symbol;Acc:1305544] |
| Ensembl ID | ENSRNOG00000007151 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 14 |
| Synonyms | cyclin-dependent kinase 14, mKIAA0834, PFTAIRE1, PFTK1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdk14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- cyclin-dependent protein kinase
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- cyclin binding
Pathways
Biological processes and signaling networks where the Cdk14 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- liver cancer
- epithelial cancer
- acute myeloid leukemia
- glomerulonephritis
- idiopathic scoliosis
- hepatocellular carcinoma
- HER2 negative hormone receptor negative breast cancer
role in cell
- tyrosine phosphorylation in
- phosphorylation in
- proliferation
- outgrowth
- growth
- serine phosphorylation in
- binding in
- invasiveness
- cell cycle progression
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdk14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- G2/M transition of mitotic cell cycle
- regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
- regulation of cell cycle
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic cyclin-dependent protein kinase holoenzyme complex
- cyclin-dependent protein kinase holoenzyme complex
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- cyclin binding
- cyclin-dependent protein kinase activity