Ccnd3 Gene Summary [Rat]
Enables protein kinase binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; hyaluronan biosynthetic process; and response to glucose. Predicted to be located in nucleoplasm. Predicted to be part of cyclin D3-CDK4 complex and cyclin D3-CDK6 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Orthologous to human CCND3 (cyclin D3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccnd3 |
| Official Name | cyclin D3 [Source:RGD Symbol;Acc:2293] |
| Ensembl ID | ENSRNOG00000050258 |
| Bio databases IDs | |
| Aliases | cyclin D3 |
| Synonyms | 9230106B05RIK, CYCD3, Cyclin D3, LOC120094634, Riken 9230106B05 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccnd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein kinase activator
- cyclin-dependent protein kinase
- protein serine/threonine kinase
- cyclin box
- LXXLL motif
- protein kinase binding
- Cyclin box fold superfamily
- Cyclin, N-terminal domain
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
- cyclin-dependent protein kinase regulator
Pathways
Biological processes and signaling networks where the Ccnd3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- Endocannabinoid Cancer Inhibition Pathway
- GADD45 Signaling
- Glioblastoma Multiforme Signaling
- Glioma Signaling
- Hereditary Breast Cancer Signaling
- IL-7 Signaling Pathway
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- Role of JAK2 in Hormone-like Cytokine Signaling
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial cancer
- hypoplasia
- hyperplasia
- myotonic dystrophy type 2
- ovarian cancer
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
role in cell
- cell death
- apoptosis
- formation in
- expression in
- quantity
- formation
- phosphorylation in
- activation in
- number
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccnd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of cyclin-dependent protein kinase activity
- positive regulation of G1/S transition of mitotic cell cycle
- signal transduction
- G1/S transition of mitotic cell cycle
- positive regulation of protein phosphorylation
- T cell proliferation
- regulation of cell proliferation
- regulation of cyclin-dependent protein kinase activity
Cellular Component
Where in the cell the gene product is active
- cyclin D3-CDK6 complex
- nucleus
- centrosome
- cytoplasm
- cyclin-dependent protein kinase holoenzyme complex
- cytosol
- nucleoplasm
- cyclin D3-CDK4 complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- cyclin-dependent protein kinase regulator activity
- protein binding
- cyclin-dependent protein kinase activity