Atp1a2 Gene Summary [Rat]
Enables several functions, including ATP binding activity; P-type sodium:potassium-exchanging transporter activity; and protein heterodimerization activity. Involved in several processes, including cellular response to mechanical stimulus; monoatomic cation transport; and regulation of cardiac muscle cell contraction. Located in several cellular components, including T-tubule; caveola; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Biomarker of hyperhomocysteinemia and hypertension. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; electroclinical syndrome (multiple); hypertension; and migraine with aura (multiple). Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp1a2 |
| Official Name | ATPase Na+/K+ transporting subunit alpha 2 [Source:RGD Symbol;Acc:2168] |
| Ensembl ID | ENSRNOG00000007290 |
| Bio databases IDs | |
| Aliases | ATPase Na+/K+ transporting subunit alpha 2 |
| Synonyms | Atpa-3, ATPase, Na+/K+ transporting, alpha 2 polypeptide, ATPase Na+/K+ transporting subunit alpha 2, ATPase Na+/K+ transporting subunit α 2, ATPase, Na+/K+ transporting, α 2 polypeptide, mKIAA0778, Na+/k+ trans2, RATATPA2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp1a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cation transporter/ATPase, N-terminus
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- ATP binding
- heavy metal translocating P-type ATPase
- enzyme
- E1-E2 ATPase
- plasma-membrane proton-efflux P-type ATPase
- copper-(or silver)-translocating P-type ATPase
- ATPase
- plasma-membrane calcium-translocating P-type ATPase
- cytoplasmic domain
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- chaperone binding
- Cation transport ATPase (P-type)
- Cation transporting ATPase, C-terminus
- hormone binding
- cation-transporting ATPase
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- golgi membrane calcium-translocating P-type ATPase
- metal ion binding
- Na+/K+-exchanging ATPase
- protein binding
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- steroid binding
- Haloacid Dehalogenase-like Hydrolases
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Atp1a2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis
- respiratory failure
- lack of spontaneous movement
- experimentally-induced diabetes
role in cell
- apoptosis
- depolarization
- action potential
- response by
- contraction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- myelin enriched fraction
- Cytoplasm
- cell surface
- intracellular membranes
- cellular membrane
- endosomes
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- costameres
- intercellular junctions
- microsome
- caveolae
- dendritic spines
- sarcolemma
- transverse tubules
- microsomal membrane
- cellular protrusions
- membrane processes
- perikaryon
- axons
- clathrin-coated vesicles