Abcb4 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and ATPase-coupled intramembrane lipid transporter activity. Involved in several processes, including cellular hyperosmotic salinity response; cellular response to L-glutamate; and cellular response to borneol. Located in apical plasma membrane and brush border membrane. Biomarker of brain disease (multiple); end stage renal disease; human immunodeficiency virus infectious disease; liver disease (multiple); and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcb4 |
| Official Name | ATP binding cassette subfamily B member 4 [Source:RGD Symbol;Acc:620248] |
| Ensembl ID | ENSRNOG00000008012 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily B member 4 |
| Synonyms | ABC21, ATP binding cassette subfamily B member 4, GBD1, ICP3, MDR2, MDR2/3, MDR3, PFIC-3, P-GP, PGY3, PHOSPHOLIPID FLIPPASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- phospholipid transporter
- type I secretion system ABC transporter, PrtD family
- glucan exporter ATP-binding protein
- linker domain
- Conjugate Transporter-2 (CT2) Family protein
- protein binding
- nitrate transport ATP-binding subunits C and D
- urea ABC transporter, ATP-binding protein UrtE
- heme ABC exporter, ATP-binding protein CcmA
- ABC transporter transmembrane region
- lipid transporter
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- phosphatidylcholine transporter
- thiol reductant ABC exporter, CydC subunit
- energy-coupling factor transporter ATPase
- nickel import ATP-binding protein NikE
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Abcb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary biliary cirrhosis
- cirrhosis
- liver cancer
- intrahepatic cholestasis of pregnancy
- progressive familial intrahepatic cholestasis type 3
- gallbladder disease type 1
- intrahepatic cholestasis of pregnancy type 3
- progressive familial intrahepatic cholestasis type 1
- cholelithiasis
- gallstone
regulated by
- deoxycholate
- hepatocytes
- 1,2-oleoylphosphatidylcholine
- adenosine triphosphate
- chenodeoxycholic acid
- methylprednisolone
- dexamethasone
- taurochenodeoxycholate
- TP53
- taurocholic acid
regulates
- D-glucose
- phospholipid
- phosphatidylcholine
- rhodamine 6G
- phosphatidylethanolamine
- sphingomyelin
- C6-NBD-PC
- lipid
- pitavastatin
- ABCB4
role in cell
- synthesis in
- cell death
- response by
- efflux in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- apical compartment
- cellular membrane
- focal adhesions
- lysosome
- intercellular junctions
- cytosol
- apical membrane
- Golgi membrane
- nucleoplasm
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of phospholipid transport
- transmembrane transport
- phospholipid translocation
- lipid homeostasis
- lipid metabolic process
- positive regulation of phospholipid translocation
- bile acid secretion
- positive regulation of cholesterol transport
Cellular Component
Where in the cell the gene product is active
- intercellular canaliculus
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane raft
- membrane
- cytosol
- clathrin-coated vesicle
- plasma membrane
- apical plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- protein binding
- phospholipid transporter activity