Ugp2 Gene Summary [Rat]
Enables D-glucose binding activity; UTP:glucose-1-phosphate uridylyltransferase activity; and pyrimidine ribonucleotide binding activity. Involved in UDP-alpha-D-glucose metabolic process and glucose 1-phosphate metabolic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ugp2 |
| Official Name | UDP-glucose pyrophosphorylase 2 [Source:RGD Symbol;Acc:1310210] |
| Ensembl ID | ENSRNOG00000008079 |
| Bio databases IDs | |
| Aliases | UDP-glucose pyrophosphorylase 2 |
| Synonyms | circRNA-UGP2, circUGP2, DEE83, EIEE83, LOC105374766, pHC379, SVUGP2, UDPG, UDP-glucose pyrophosphorylase 2, UDPGP, UDPGP 1, UDPGP2, UGP1, UGPase, UGPP1, UGPP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ugp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UTP-glucose-1-phosphate uridylyltransferase
- nucleotide binding
- binding protein
- nucleotidyltransferase
- glucose binding
- UTP--glucose-1-phosphate uridylyltransferase
- enzyme
- protein binding
- pyrimidine nucleotide binding
- glycosyltransferase family A
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- non-insulin-dependent diabetes mellitus
- neoplasia
- insomnia
- developmental and epileptic encephalopathy type 83
- colorectal adenoma
- colorectal adenoma formation
- progressive familial intrahepatic cholestasis type 1
role in cell
- growth
- binding
- N-glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ugp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen biosynthetic process
- glycogen metabolic process
- glucose 1-phosphate metabolic process
- UDP-glucose metabolic process
- brain development
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- glucose binding
- identical protein binding
- protein binding
- metal ion binding
- pyrimidine ribonucleotide binding
- UTP:glucose-1-phosphate uridylyltransferase activity