UGP2 Gene Summary [Human]
The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | UGP2 |
| Official Name | UDP-glucose pyrophosphorylase 2 [Source:HGNC Symbol;Acc:HGNC:12527] |
| Ensembl ID | ENSG00000169764 |
| Bio databases IDs | |
| Aliases | UDP-glucose pyrophosphorylase 2, UTP--glucose-1-phosphate uridylyltransferase |
| Synonyms | circRNA-UGP2, circUGP2, DEE83, EIEE83, LOC105374766, pHC379, SVUGP2, UDPG, UDP-glucose pyrophosphorylase 2, UDPGP, UDPGP 1, UDPGP2, UGP1, UGPase, UGPP1, UGPP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UGP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UTP-glucose-1-phosphate uridylyltransferase
- nucleotide binding
- binding protein
- nucleotidyltransferase
- glucose binding
- UTP--glucose-1-phosphate uridylyltransferase
- enzyme
- protein binding
- pyrimidine nucleotide binding
- glycosyltransferase family A
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- non-insulin-dependent diabetes mellitus
- neoplasia
- insomnia
- developmental and epileptic encephalopathy type 83
- colorectal adenoma
- colorectal adenoma formation
- progressive familial intrahepatic cholestasis type 1
role in cell
- growth
- binding
- N-glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UGP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen biosynthetic process
- glycogen metabolic process
- glucose 1-phosphate metabolic process
- UDP-glucose metabolic process
- brain development
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- glucose binding
- identical protein binding
- protein binding
- metal ion binding
- pyrimidine ribonucleotide binding
- UTP:glucose-1-phosphate uridylyltransferase activity