Txndc12 Gene Summary [Rat]
Predicted to enable protein-disulfide reductase (glutathione) activity. Predicted to act upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum lumen. Orthologous to human TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Txndc12 |
| Official Name | thioredoxin domain containing 12 [Source:RGD Symbol;Acc:1305960] |
| Ensembl ID | ENSRNOG00000008090 |
| Bio databases IDs | |
| Aliases | thioredoxin domain containing 12 |
| Synonyms | 0610040B21Rik, AG1, AGR1, ERP16, ERP18, ERP19, hAG-1, hTLP19, PDIA16, RGD1305960, thioredoxin domain containing 12, thioredoxin domain containing 12 (endoplasmic reticulum), TLP19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Txndc12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide oxidoreductase
- Thioredoxin-like
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein-disulfide reductase (glutathione)
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
role in cell
- production in
- cell death
- peroxidation in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Txndc12 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein disulfide oxidoreductase activity
- protein binding
- protein-disulfide reductase (glutathione) activity