Syn2 Gene Summary [Rat]
Enables calcium-dependent protein binding activity. Predicted to be involved in secretion by cell; synapse organization; and synaptic vesicle clustering. Located in synaptic vesicle. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SYN2 (synapsin II). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syn2 |
| Official Name | synapsin II [Source:RGD Symbol;Acc:3798] |
| Ensembl ID | ENSRNOG00000008157 |
| Bio databases IDs | |
| Aliases | synapsin II |
| Synonyms | 2900074L19Rik, AI841723, synapsin II, SYNII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Syn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- cytoskeletal protein binding
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- ATP binding
- Synapsin N-terminal
- protein binding
- alpha-L-glutamate ligase, RimK family
- Synapsin, N-terminal domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acne
- epithelial cancer
- chronic obstructive pulmonary disease
- COVID-19
- schizophrenia
- depressive disorder
- metabolic syndrome X
- tonic-clonic seizure
- idiopathic scoliosis
- seizures
role in cell
- formation
- synaptic depression
- activity
- transmission
- association
- maintenance
- clustering
- abnormal morphology
- abnormal quantity
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- membrane fraction
- synaptic vesicle membrane
- glutaminergic synapse
- cellular membrane
- synaptic vesicles
- growth cone
- neurites
- synaptosomes
- synapse
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Syn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission
- synaptic vesicle clustering
- calcium ion-dependent exocytosis
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- SNARE complex
- synapse
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding