Chmp2b Gene Summary [Rat]
Predicted to enable protein domain specific binding activity. Involved in modulation of chemical synaptic transmission; regulation of modification of postsynaptic structure; and regulation of postsynapse organization. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; frontotemporal dementia; and frontotemporal dementia and/or amyotrophic lateral sclerosis 7. Orthologous to human CHMP2B (charged multivesicular body protein 2B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chmp2b |
| Official Name | charged multivesicular body protein 2B [Source:RGD Symbol;Acc:1306781] |
| Ensembl ID | ENSRNOG00000040257 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 2B |
| Synonyms | 1190006E07RIK, ALS17, charged multivesicular body protein 2B, CHMP2.5, DKFZP564O123, DMT1, FTDALS7, RGD1306781, VPS2-2, VPS2B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chmp2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein domain specific binding
- protein binding
- Snf7
Pathways
Biological processes and signaling networks where the Chmp2b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis type 17
- non-insulin-dependent diabetes mellitus
- peripheral arterial disease
- periodontitis
- frontotemporal lobar degeneration
role in cell
- damage in
- expression in
- accumulation in
- damage
- quantity
- loss
- autophagy by
- density
- branching
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- somatodendritic region
- cellular membrane
- Plasma Membrane
- endosomes
- lysosome
- midbody
- cytosol
- lysosome membrane
- nuclear pores
- dendritic spines
- synaptosomes
- autophagic vacuoles
- late endosomes
- multivesicular bodies
- kinetochore microtubule
- kinetochores
- postsynaptic density
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chmp2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- endosome organization
- protein transport
- late endosome to vacuole transport
- nucleus organization
- neuron homeostasis
- release of virus from host
- regulation of centrosome duplication
- non-lytic virus budding from plasma membrane
- cognition
- plasma membrane repair
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- autophagy
- endosome transport via multivesicular body sorting pathway
- multivesicular body sorting pathway
- regulation of synaptic transmission
- nuclear envelope reassembly
- mitotic metaphase plate congression
- macroautophagy
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- ESCRT III complex
- late endosome
- multivesicular body
- kinetochore
- lysosomal membrane
- plasma membrane
- autophagic vacuole membrane
- nuclear pore
- lysosome
- endosome
- extracellular vesicular exosome
- cytoplasm
- kinetochore microtubule
- cytosol
- midbody
- multivesicular body membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- cadherin binding