Xpc Gene Summary [Rat]
Predicted to enable several functions, including DNA binding activity; DNA damage sensor activity; and transcription coactivator activity. Involved in response to auditory stimulus and response to xenobiotic stimulus. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nuclear lumen. Predicted to be part of XPC complex and nucleotide-excision repair factor 2 complex. Predicted to be active in cytoplasm and site of DNA damage. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xpc |
| Official Name | XPC complex subunit, DNA damage recognition and repair factor [Source:RGD Symbol;Acc:1305760] |
| Ensembl ID | ENSRNOG00000008274 |
| Bio databases IDs | |
| Aliases | XPC complex subunit, DNA damage recognition and repair factor |
| Synonyms | ERCM1, p125, RAD4, xeroderma pigmentosum, complementation group C, XP3, XPCC, XPC complex subunit, DNA damage recognition and repair factor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Xpc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rad4 beta-hairpin domain 2
- DNA repair protein rad4
- transcription regulator
- transcription co-activator
- Rad4 beta-hairpin domain 3
- DNA secondary structure binding
- transcription factor binding
- protein binding
- damaged DNA binding
- binding protein
- single-stranded DNA binding
- double-stranded DNA binding
- Rad4 beta-hairpin domain 1
Pathways
Biological processes and signaling networks where the Xpc gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- hyperplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- adenoma formation
- benign neoplasia
- tumorigenesis
- xeroderma pigmentosum complementation group C
role in cell
- phosphorylation in
- expression in
- binding
- apoptosis
- activation in
- number
- growth
- quantity
- activity
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Xpc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- UV-damage excision repair
- positive regulation of transcription, DNA-dependent
- response to auditory stimulus
- nucleotide-excision repair
- intra-S DNA damage checkpoint
- mismatch repair
- response to xenobiotic stimulus
- pyrimidine dimer repair by nucleotide-excision repair
- response to UV-B
Cellular Component
Where in the cell the gene product is active
- nucleotide-excision repair complex
- nucleolus
- chromatin
- plasma membrane
- nucleoplasm
- nucleotide-excision repair factor 2 complex
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- XPC complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- bubble DNA binding
- loop DNA binding
- damaged DNA binding
- single-stranded DNA binding