Nav1 Gene Summary [Rat]
Predicted to enable ATP hydrolysis activity. Predicted to be involved in microtubule bundle formation and neuron migration. Predicted to be active in axon initial segment and microtubule cytoskeleton. Orthologous to human NAV1 (neuron navigator 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nav1 |
| Official Name | neuron navigator 1 [Source:RGD Symbol;Acc:1590261] |
| Ensembl ID | ENSRNOG00000008425 |
| Bio databases IDs | |
| Aliases | neuron navigator 1 |
| Synonyms | 9530089B19, 9930003A20Rik, BC028801, C230080M11Rik, Gm38399, LOC685727, mKIAA1151, neuron navigator 1, POMFIL3, STEERIN1, UNC53H1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nav1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ezrin/radixin/moesin, alpha-helical domain
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- pervasive developmental disorder
- insomnia
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- chronic obstructive pulmonary disease
- cardiovascular disorder
- Down syndrome
- prostatic carcinoma
- celiac disease
role in cell
- migration
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- microtubule cytoskeleton
- axon component
- axon initial segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nav1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- microtubule bundle formation
- nervous system development
Cellular Component
Where in the cell the gene product is active
- initial segment
- microtubule cytoskeleton
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- protein binding