Ppp1r9a Gene Summary [Rat]
Enables several functions, including actin filament binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of actin filament organization; and regulation of synapse organization. Acts upstream of or within neuron projection development. Located in several cellular components, including dendritic spine neck; growth cone lamellipodium; and neuromuscular junction. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Used to study transient cerebral ischemia. Biomarker of hepatocellular carcinoma. Orthologous to human PPP1R9A (protein phosphatase 1 regulatory subunit 9A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r9a |
| Official Name | protein phosphatase 1, regulatory subunit 9A [Source:RGD Symbol;Acc:632280] |
| Ensembl ID | ENSRNOG00000008869 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 9A |
| Synonyms | 2810430P21RIK, 4930518N04Rik, 5330407E15, A230094E16Rik, Nb, Neb1, Neurabin1, Neurabin-I, Nrb, NRB1, NRBI, p180, PP1bp175, protein phosphatase 1 regulatory subunit 9A, protein phosphatase 1, regulatory subunit 9A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp1r9a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein kinase binding
- SAM domain
- SAM (Sterile alpha motif )
- canonical PDZ domain
- enzyme binding
- PP1 binding domain
- coiled-coil domain
- protein domain specific binding
- protein binding
- PDZ domain
- identical protein binding
- actin filament binding
- Sterile alpha motif
- actin-binding domain
- F-actin binding domain
- protein phosphatase 1 binding
- binding protein
- SAM domain (Sterile alpha motif)
- ion channel binding
- cpPDZ_Deg_HtrA-like
- Domain of unknown function (DUF4472)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- coronary artery disease
- insomnia
- seizures
role in cell
- survival
- cell death
- density
- long-term potentiation
- formation
- development
- maturation
- function
- synaptic transmission
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- cortical actin cytoskeleton
- cytoskeleton
- Cytoplasm
- actin cytoskeleton
- dendritic spines
- dendritic spine neck
- neuromuscular junctions
- growth cone
- neurites
- synaptosomes
- filopodia
- perikaryon
- dendrites
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp1r9a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- actin filament organization
- regulation of synaptic transmission
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- cytoplasm
- dendritic spine
- actin cytoskeleton
- filopodium
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding