Plcg1 Gene Summary [Rat]
Enables several functions, including guanyl-nucleotide exchange factor activity; insulin receptor binding activity; and phospholipase C activity. Involved in several processes, including inositol trisphosphate biosynthetic process; positive regulation of cell size; and regulation of store-operated calcium channel activity. Located in clathrin-coated vesicle. Biomarker of acute myocardial infarction and colon cancer. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung non-small cell carcinoma. Orthologous to human PLCG1 (phospholipase C gamma 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plcg1 |
| Official Name | phospholipase C, gamma 1 [Source:RGD Symbol;Acc:3347] |
| Ensembl ID | ENSRNOG00000051490 |
| Bio databases IDs | |
| Aliases | phospholipase C, gamma 1 |
| Synonyms | CDED, IDAA, NCKAP3, phospholipase C gamma 1, phospholipase C, gamma 1, phospholipase C-γ-1, phospholipase C, γ 1, PIPLC gamma, PIPLC γ, PLC1, PLC148, PLC Gamma, PLCgamma1, PLC-II, PLC γ, PPLCA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plcg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- insulin receptor binding
- phosphoprotein binding
- enzyme
- EFh_PI-PLC
- Phosphatidylinositol-specific phospholipase C, X domain
- C2-like domain
- Phospholipase C, catalytic domain (part: domain X)
- receptor tyrosine kinase binding
- Phospholipase C, catalytic domain (part: domain Y)
- Src homology 2 (SH2) domain
- C2 domain
- Phosphatidylinositol-specific phospholipase C, Y domain
- protein kinase binding
- catalytic domain
- Lipase domain
- phospholipase C
- protein binding
- receptor binding
- Pleckstrin homology-like domain
- Src-homology 2 binding domain
- neurotrophin TRKA receptor binding
- Src Homology 3 domain superfamily
- beta strand or sheet
- calcium-dependent phospholipase C
- phosphoinositide phospholipase C
- guanyl-nucleotide exchange factor
- hinge domain
- Protein kinase C conserved region 2 (CalB)
Pathways
Biological processes and signaling networks where the Plcg1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Apoptosis Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chemokine Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- eNOS Signaling
- ErbB4 Signaling
- Fc Epsilon RI Signaling
- FGF Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- Macropinocytosis Signaling
- Neurotrophin/TRK Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Prolactin Signaling
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Systemic Lupus Erythematosus Signaling
- Thrombopoietin Signaling
- TREM1 Signaling
- UVA-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- neoplasia
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- preeclampsia
- myocardial infarction
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- angioimmunoblastic T-cell lymphoma
role in cell
- migration
- invasion
- apoptosis
- differentiation
- activation in
- production in
- binding in
- survival
- cell viability
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- membrane/cytoplasmic fraction
- glutaminergic synapse
- ruffle
- cytoskeleton
- cellular membrane
- focal adhesions
- Plasma Membrane
- endosomes
- intercellular junctions
- cytosol
- membrane ruffles
- outer leaflet
- zymogen granules
- synapse
- membrane rafts
- cellular protrusions
- clathrin-coated vesicles
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plcg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epidermal growth factor receptor signaling pathway
- phospholipid catabolic process
- Fc-epsilon receptor signaling pathway
- phosphatidylinositol metabolic process
- positive regulation of release of sequestered calcium ion into cytosol
- positive regulation of angiogenesis
- positive regulation of blood vessel endothelial cell migration
- negative regulation of inflammatory response to antigenic stimulus
- in utero embryonic development
- phosphatidylinositol-mediated signaling
- cellular response to epidermal growth factor stimulus
- regulation of synaptic transmission
- positive regulation of endothelial cell apoptotic process
- release of sequestered calcium ion into cytosol
- positive regulation of epithelial cell migration
- calcium-mediated signaling
- cell migration
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoplasm
- ruffle
- ruffle membrane
- cytosol
- signalosome
- cell projection
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein kinase binding
- glutamate receptor binding
- protein binding
- calcium ion binding
- phospholipase C activity
- guanyl-nucleotide exchange factor activity
- calcium-dependent phospholipase C activity
- receptor tyrosine kinase binding
- neurotrophin TRKA receptor binding