Gas2l1 Gene Summary [Mouse]
This gene encodes a member of the Gas2 family, actin-associated proteins expressed at high levels in growth-arrested cells. The gene expression is negatively regulated by serum and growth factors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | Gas2l1 |
| Official Name | growth arrest-specific 2 like 1 [Source:MGI Symbol;Acc:MGI:1926176] |
| Ensembl ID | ENSMUSG00000034201 |
| Bio databases IDs | |
| Aliases | growth arrest-specific 2 like 1 |
| Synonyms | 4930500E24RIK, D0Jmb1, GAR22, growth arrest-specific 2 like 1, MGC17243, TU-71.1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gas2l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Calponin homology domain
- calponin homology (CH) domain superfamily
- protein binding
- glycine arginine rich domain
- Growth-Arrest-Specific Protein 2 Domain
- cytoskeletal adaptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
role in cell
- morphology
- binding in
- density
- quantity
- assembly
- assembly in
- formation
- length
- motility
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- actin filaments
- sperm head
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gas2l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actin crosslink formation
- microtubule bundle formation
- regulation of microtubule polymerization or depolymerization
- cellular response to starvation
Cellular Component
Where in the cell the gene product is active
- microtubule plus end
- cytoplasm
- stress fiber
- actin filament
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- cytoskeletal adaptor activity
- protein binding
- microtubule binding