Dusp1 Gene Summary [Rat]
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | Dusp1 |
| Official Name | dual specificity phosphatase 1 [Source:RGD Symbol;Acc:620897] |
| Ensembl ID | ENSRNOG00000003977 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 1 |
| Synonyms | 3CH134, BAD2, CL100, dual specificity phosphatase 1, erp, Growth factor-inducible immediate early, HVH1, MAP KINASE PHOSPHATASE 1, MKP-1, MPK-1, Osiptpase, Ptpase, PTPN10, PTPN16, PTP Non-Receptor Type16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dusp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein tyrosine/serine/threonine phosphatase
- protein-tyrosine-phoshatase
- phosphoprotein phosphatase
- protein serine/threonine phosphatase
- protein tyrosine/threonine phosphatase
- Rhodanese Homology Domain
- protein binding
- Rhodanese-like domain
- PTP_DSP_cys
- RHOD
- Dual specificity phosphatase, catalytic domain
- MAP kinase phosphatase
- phosphatase
- serine phosphorylation site
- growth factor binding
Pathways
Biological processes and signaling networks where the Dusp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- reperfusion injury
- rheumatoid arthritis
- psoriasis
- prostate cancer
- atopic dermatitis
- Duchenne muscular dystrophy
- COVID-19
- Alzheimer disease
- prostatic carcinoma
role in cell
- expression in
- production in
- apoptosis
- cell death
- proliferation
- cell movement
- activation in
- phosphorylation in
- quantity
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dusp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-serine dephosphorylation
- negative regulation of monocyte chemotaxis
- peptidyl-threonine dephosphorylation
- negative regulation of MAP kinase activity
- negative regulation of MAPK cascade
- negative regulation of cell adhesion
- negative regulation of cell proliferation
- regulation of mitotic cell cycle spindle assembly checkpoint
- endoderm formation
- peptidyl-tyrosine dephosphorylation
- negative regulation of meiotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- MAP kinase tyrosine phosphatase activity
- protein tyrosine/threonine phosphatase activity
- protein tyrosine phosphatase activity
- mitogen-activated protein kinase binding
- MAP kinase tyrosine/serine/threonine phosphatase activity
- protein tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity