Mre11a

Enables nuclease activity. Involved in DNA strand resection involved in replication fork processing; chromosome organization; and double-strand break repair via homologous recombination. Acts upstream of or within several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint signaling. Located in PML body. Part of Mre11 complex. Colocalizes with chromosome, telomeric region. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mre11a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Mre11a gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Mre11a gene, providing context for its role in the cell.