Dusp10 Gene Summary [Rat]
Predicted to enable phosphoprotein phosphatase activity and protein kinase binding activity. Involved in negative regulation of oligodendrocyte differentiation. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Biomarker of pancreatitis. Orthologous to human DUSP10 (dual specificity phosphatase 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dusp10 |
| Official Name | dual specificity phosphatase 10 [Source:RGD Symbol;Acc:1310844] |
| Ensembl ID | ENSRNOG00000004003 |
| Bio databases IDs | |
| Aliases | dual specificity phosphatase 10 |
| Synonyms | 2610306G15Rik, dual specificity phosphatase 10, MKP-5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dusp10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- catalytic domain
- phosphoprotein phosphatase
- protein tyrosine/threonine phosphatase
- Rhodanese Homology Domain
- mitogen-activated protein kinase p38 binding
- JUN kinase binding
- PTP_DSP_cys
- protein binding
- Rhodanese-like domain
- RHOD
- Dual specificity phosphatase, catalytic domain
- MAP kinase phosphatase
- phosphatase
Pathways
Biological processes and signaling networks where the Dusp10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- Waldenström macroglobulinemia
- cardiac fibrosis
- chronic lymphocytic leukemia
- dextran sodium sulfate-induced colitis
- experimental autoimmune encephalomyelitis
- hepatic injury
- rheumatic fever
role in cell
- cell viability
- expression in
- activation in
- phosphorylation in
- proliferation
- growth
- production in
- formation
- number
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dusp10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte differentiation
- regulation of brown fat cell differentiation
- negative regulation of respiratory burst involved in inflammatory response
- peptidyl-threonine dephosphorylation
- negative regulation of JUN kinase activity
- negative regulation of JNK cascade
- negative regulation of oligodendrocyte differentiation
- positive regulation of regulatory T cell differentiation
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of epithelial cell proliferation
- negative regulation of epithelial cell migration
- negative regulation of stress-activated MAPK cascade
- response to lipopolysaccharide
- dephosphorylation
- regulation of adaptive immune response
- peptidyl-tyrosine dephosphorylation
- negative regulation of cell migration
- stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- MAP kinase phosphatase activity
- mitogen-activated protein kinase p38 binding
- MAP kinase tyrosine phosphatase activity
- protein tyrosine/threonine phosphatase activity
- phosphatase activity
- JUN kinase binding
- MAP kinase tyrosine/serine/threonine phosphatase activity
- myosin phosphatase activity