Pgm3 Gene Summary [Rat]
Predicted to enable phosphoacetylglucosamine mutase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process; hemopoiesis; and protein glycosylation. Predicted to act upstream of or within spermatogenesis. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgm3 |
| Official Name | phosphoglucomutase 3 [Source:RGD Symbol;Acc:1305221] |
| Ensembl ID | ENSRNOG00000009515 |
| Bio databases IDs | |
| Aliases | phosphoglucomutase 3 |
| Synonyms | 2810473H05Rik, AGM1, IMD23, N-acetylglucosamine phosphate mutase, PAGM, phosphoglucomutase 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pgm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphohexomutase
- Phosphoglucomutase/phosphomannomutase, C-terminal domain
- phosphoacetylglucosamine mutase
- phosphoglucosamine mutase
- enzyme
- phosphoglucomutase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- thrombocytopenia
- leukopenia
- schizophrenia
- immunodeficiency 23
- anemia
- severe combined immunodeficiency
- insomnia
- hyper-IgE syndrome
- hereditary disorder
regulates
- ACE
- UDP-N-acetylglucosamine
role in cell
- hematopoiesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pgm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- protein O-linked glycosylation
- spermatogenesis
- hemopoiesis
- glucosamine metabolic process
- protein N-linked glycosylation
- UDP-N-acetylglucosamine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- phosphoacetylglucosamine mutase activity