Cyb5r3 Gene Summary [Rat]
Enables cytochrome-b5 reductase activity, acting on NAD(P)H and nucleotide binding activity. Predicted to be involved in nitric oxide biosynthetic process. Located in endoplasmic reticulum membrane and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R3 (cytochrome b5 reductase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyb5r3 |
| Official Name | cytochrome b5 reductase 3 [Source:RGD Symbol;Acc:2502] |
| Ensembl ID | ENSRNOG00000009592 |
| Bio databases IDs | |
| Aliases | cytochrome b5 reductase 3 |
| Synonyms | 0610016L08Rik, 2500002N19Rik, B5R, C85115, cytochrome b5 reductase 3, DIA1, Nadhcb5, NADH Cytochrome B5 Reductase, RNNADHCB5, WU:Cyb5r3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyb5r3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- FNR_like
- flavin adenine dinucleotide binding
- ADP binding
- cytochrome-b5 reductase
- enzyme
- protein binding
- nitrite reductase
- Oxidoreductase FAD-binding domain
- FAD binding
- NAD or NADH binding
- AMP binding
- linoleoyl-CoA desaturase
- Oxidoreductase NAD-binding domain
Pathways
Biological processes and signaling networks where the Cyb5r3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- lung squamous cell carcinoma
- squamous cell lung cancer
- methemoglobinemia type II
- maple syrup urine disease type 3
- breast cancer
- preeclampsia
- methemoglobinemia type I
- microcephaly
role in cell
- cell death
- expression in
- production in
- formation
- growth
- generation
- killing
- ADP ribosylation in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- myoendothelial junction
- azurophil granule lumen
- Extracellular Space
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- midbody
- lipid droplets
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- mitochondrial membrane
- mitochondrial outer membrane
- nuclear envelope
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyb5r3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cholesterol biosynthetic process
- blood circulation
- nitric oxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- hemoglobin complex
- endoplasmic reticulum membrane
- lipid particle
- mitochondrial membrane
- cytoplasm
- mitochondrion
- membrane
- endoplasmic reticulum
- extracellular region
- mitochondrial outer membrane
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- cytochrome-b5 reductase activity
- FAD binding
- protein binding
- AMP binding
- nitrite reductase (NO-forming) activity
- NAD binding
- ADP binding