Me1 Gene Summary [Rat]
Enables NADP binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in response to hormone. Located in cytosol and mitochondrion. Orthologous to human ME1 (malic enzyme 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Me1 |
| Official Name | malic enzyme 1 [Source:RGD Symbol;Acc:3074] |
| Ensembl ID | ENSRNOG00000009715 |
| Bio databases IDs | |
| Aliases | malic enzyme 1 |
| Synonyms | BRCAME, D9Ertd267e, HUMNDME, Malate Nadp Oxyreductase, Malic enzyme, malic enzyme 1, malic enzyme 1, NADP(+)-dependent, cytosolic, Mdh-1, MES, MOD1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Me1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- electron carrier
- oxaloacetate decarboxylase
- Malic enzyme, N-terminal domain
- ADP binding
- enzyme
- protein binding
- magnesium ion binding
- malate dehydrogenase (oxaloacetate-decarboxylating) (NADP)
- identical protein binding
- NAD or NADH binding
- NADP binding
- malic enzyme
- manganese ion binding
Pathways
Biological processes and signaling networks where the Me1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- psoriasis
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- pancreatic epithelial cancer
- bipolar disorder
- actinic keratosis
- nonalcoholic steatohepatitis
- diabetic nephropathy
- vascular dementia
role in cell
- production in
- activation in
- proliferation
- senescence
- growth
- invasion by
- metabolism in
- migration
- glycolysis in
- lipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Me1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- NADH metabolic process
- malate metabolic process
- protein homotetramerization
- nucleotide biosynthetic process
- NADP metabolic process
- response to carbohydrate stimulus
- response to hormone stimulus
- pyruvate metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- oxaloacetate decarboxylase activity
- magnesium ion binding
- NADP binding
- identical protein binding
- protein binding
- NAD binding
- malic enzyme activity
- electron carrier activity
- manganese ion binding
- ADP binding
- malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity