ME1 Gene Summary [Human]
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ME1 |
| Official Name | malic enzyme 1 [Source:HGNC Symbol;Acc:HGNC:6983] |
| Ensembl ID | ENSG00000065833 |
| Bio databases IDs | |
| Aliases | malic enzyme 1, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), NADP-dependent malic enzyme |
| Synonyms | BRCAME, D9Ertd267e, HUMNDME, Malate Nadp Oxyreductase, Malic enzyme, malic enzyme 1, malic enzyme 1, NADP(+)-dependent, cytosolic, Mdh-1, MES, MOD1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ME1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- electron carrier
- oxaloacetate decarboxylase
- Malic enzyme, N-terminal domain
- ADP binding
- enzyme
- protein binding
- magnesium ion binding
- malate dehydrogenase (oxaloacetate-decarboxylating) (NADP)
- identical protein binding
- NAD or NADH binding
- NADP binding
- malic enzyme
- manganese ion binding
Pathways
Biological processes and signaling networks where the ME1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- psoriasis
- epithelial cancer
- non-insulin-dependent diabetes mellitus
- pancreatic epithelial cancer
- bipolar disorder
- actinic keratosis
- nonalcoholic steatohepatitis
- diabetic nephropathy
- vascular dementia
role in cell
- production in
- activation in
- proliferation
- senescence
- growth
- invasion by
- metabolism in
- migration
- glycolysis in
- lipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ME1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- NADH metabolic process
- malate metabolic process
- protein homotetramerization
- nucleotide biosynthetic process
- NADP metabolic process
- response to carbohydrate stimulus
- response to hormone stimulus
- pyruvate metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- oxaloacetate decarboxylase activity
- magnesium ion binding
- NADP binding
- identical protein binding
- protein binding
- NAD binding
- malic enzyme activity
- electron carrier activity
- manganese ion binding
- ADP binding
- malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity